• Nakano T, Akamatsu K, Tsuda M, Tsujimoto A, Hirayama R, Hiromoto T, Tamada T, Ide H, Shikazono N. Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy. Proc Natl Acad Sci U S A. 119(13):e2119132119 (2022)
  • Hirota K, Ooka M, Shimizu N, Yamada K, Tsuda M, Ibrahim MA, Yamada S, Sasanuma H, Masutani M, Takeda S. XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA. Genes Cells.(2022)
  • Tsuda M, Shimizu N, Tomikawa H, Morozumi R, Ide H. Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells. J Radiat Res. 62(6):999-1004 (2021)
  • Saha Lk, Murai Y, Saha S, Jo U, Tsuda M, Takeda S, Pommier Y. Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexed. Nucleic Acids Res. 49(18):10493-10506 (2021)
  • Kratz K, Artola-Borán M, Kobayashi-Era S, Koh G, Oliveira G, Kobayashi S, Oliveira A, Zou X, Richter J, Tsuda M, Sasanuma H, Takeda S, Loizou IJ, Sartori AA, Nik-Zainal S, Jiricny J. FANCD2-associated nuclease 1 partially compensates for the lack of Exonuclease 1 in mismatch repair. Mol Cell Biol.41(9):e0030321 (2021)
  • Demin AA*, Hirota K*, Tsuda M (co-first author)*, Adamowicz M,Hailstone R, Brazina J,Gittens W, Kalasova I, Shao Z, Zha S, SasanumaH, Hanzlikova, Takeda S, Caldecott KW. XRCC1 prevents toxic PARP1 trapping duringDNA base excision repair. Mol Cell. 81(14):3018-3030.e5 (2021)
  • Inomata Y, Abe T, Tsuda M, Takeda S, Hirota K. Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage. PLoS One. 16(6):e0252587 (2021)
  • Rahman MM, Mohiuddin, Shamima Keka I, Yamada K, Tsuda M, Sasanuma H, Andreani J, Guerois R, Borde V, Charbonnier JB, Takeda S. Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination. J Biol Chem. jbc.RA120.013521 – jbc.RA120.013521 (2020)
  • Sasanuma H, Yamada S, Tsuda M, Takeda S Restoration of ligatable “clean” double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage DNA Repair 93 102913 – 102913 (2020)
  • Nakano T, Shoulkamy M, Tsuda M, Sasanuma H, Takata M, Masunaga S, Takeda S, Ide H, Bessho T, Tano K. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. PLoS One. 15(6)e0234859-e0234859 (2020)
  • Tsuda M, Kitamasu K, Kumagai C, Sugiyama K, Nakano T, Ide H. Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3’-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). DNA Repair (Amst). 91-92 102849 – 102849 (2020)
  • Akagawa R, Trinh HT, Saha LK , Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H. UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks. iScience. 23(4):101027 (2020)
  • Itou J, Takahashi R, Sasanuma H, Tsuda M, Morimoto S, Matsumoto Y, Ishii T, Sato F, Takeda S, Toi M. Estrogen induces mammary ductal dysplasia via upregulation of Myc expression in a DNA-repair-deficient condition. iScience. 23(2):100821 (2020)
  • Xu X, Nakano T, Tsuda M, Kanamoto R, Hirayama R, Uzawa A, Ide H. Direct observation of damage clustering in irradiated DNA with atomic force microscopy. Nucleic Acids Research. 48(3):e18 (2020)
  • Tsuda M, Kitamasu K, Hosokawa S, Nakano T, Ide, H. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms. Nucleosides, Nucleotides & Nucleic Acids. 39(1-3):170-184 (2020)
  • Sassa A., Tada H, Harada K, Suzuki M, Tsuda M, Sasanuma H, Takeda S, Sugasawa K, Yasui M, Honma M, Ura K. Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η. Sci Rep. 9(1):13910 (2019)
  • Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S. PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching. PLoS One. 14(3):e0213383. (2019)
  • Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S. Type II DNA Topoisomerase cause spontaneous double-strand breaks in genomic DNA. Genes (Basel). 10(11). pii: E868 (2019)
  • Mohiuddin, Evans TJ, Rahman MM, Keka IS, Tsuda M, Sasanuma H, Takeda S. SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines. Proc Natl Acad Sci U S A. 115(50):12793-12798 (2018)
  • Sasanuma H*, Tsuda M*(Equal contribution), Morimoto S*, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada, S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Proc Natl Acad Sci U S A. 115(45):E10642-E10651. (2018)
  • Ide H, Nakano T, Salem AMH, Shoulkamy MI. DNA-protein cross-links: Formidable challenges to maintaining genome integrity. DNA Repair (Amst). 71:190-197(2018)
  • Nakamae K, Nishimura Y, Takenaga M, Nakade S, Sakamoto N, Ide H, Sakuma T, Yamamoto T. Establishment of expanded and streamlined pipeline of PITCh knock-in – a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO. Bioengineered. 8(3):302-308 (2017)
  • Zhang, Y., Matsuzaka, T., Yano, H., Furuta, Y., Nakano, T., Ishikawa, K., Fukuyo, M., Takahashi, N., Suzuki, Y., Sugano, S., Ide, H,. and Kobayashi, I. Restriction glycosylases: involvement of endonuclease activities in the restriction process. Nucleic Acids Res 45, 1392-1403. (2017)
  • Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui Y, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K. ALC1/CHD1L, chromatin-remodeling enzyme, is required for efficient base excision repair. PLoS One. 12(11):e0188320 (2017)
  • Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Res. 45(17):10079-10088 (2017)
  • Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. PLoS One. 12(9):e0185141 (2017)
  • Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K. The Dominant Role of Proofreading Exonuclease Activity of Replicative Polymerase ε in Cellular Tolerance to Cytarabine (Ara-C). Oncotarget. 8(20):33457-33474 (2017)
  • Nakano, T., Xu Xu, Salem, A. M., and Ide, H. Radiation-induced DNA-protein cross-links:Mechanisms and biological significants Free Radic Biol Med S0891-5849(16), 31075-9. (2017)
  • Xie, M. Z., Shoulkamy, M. I., Salem, A. M., Oba, S., Goda, M., Nakano, T., and Ide, H. Aldehydes with high and low toxicities inactivate cells by damaging distinct cellular targets. Mutat Res 786, 41-51. (2016)
  • Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Mre11 is essential for the removal of lethal topoisomerase 2 covalent cleavage complexes. Mol Cell. 64 (3): 580-592. (2016)
  • Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K. Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides. Cell Cycle. 15 (15): 1997-2008. (2016)
  • Hirota K*, Tsuda M Equal conribution *, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda T. In vivo evidence for translesion synthesis by the replicative DNA polymerase δ. Nucleic Acids Res. 44 (15): 7242-7250. (2016)
  • Nakano, T., Mitsusada, Y., Salem, A. M., Shoulkamy, M. I., Sugimoto, T., Hirayama, R., Uzawa, A., Furusawa, Y., and Ide, H. Induction of DNA-protein cross-links by ionizing radiation and their elimination from the genome. Mutat Res 771, 45-50. (2015)
  • Fukuyo, M.*, Nakano, T.,*, Zhang, Y., Furuta, Y., Ishikawa, K., Watanabe-Matsui, M., Yano, H., Hamakawa, T., Ide, H., and Kobayashi, I. Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities. Nucleic Acids Res 43, 2841-2852. *Equal contribution (2015)
  • Matsumoto Y, Rodriguez V, Whitford TA, Beeharry N, Ide H, Tomkinson AE. Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells. Oncoscience. 2(3):272-284(2015)
  • Yamamoto R, Umetsu M, Yamamoto M, Matsuyama S, Takenaka S, Ide H, Kubo K. AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts. J Radiat Res. 56(3):462-466 (2015)
  • Tokuyama Y, Furusawa Y, Ide H, Yasui A, Terato H. Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation. J Radiat Res.56(3):446-455. (2015)
  • Ide, H., Nakano, T., Shoulkamy, M. I., and Salem, A. M. Formation, repair, and biological effects of DNA–protein cross-link damage. In Advances in DNA Reapir (Chen C.C.. ed.), pp. 43-80, InTech, Croatia. (2015)
  • Miyamoto-Matsubara, M., Han, Y., Ono, K., Xie, M., Salem, A. M., Shoulkamy, M. I., Nakano, T., and Ide, H. Depletion of RUVBL2 in human cells confers moderate sensitivity to anticancer agents. J Cancer Sci Ther 6, 440-445. (2014)
  • Hirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips L, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann, A, Sale J, Takeda S. The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ. Nucleic Acids Res. 43 (3): 1671-1683 (2015).
  • Yamamoto R, Ohshiro Y, Shimotani T, Yamamoto M, Matsuyama S, Ide H, Kubo K. Hypersensitivity of mouse NEIL1-knockdown cells to hydrogen peroxide during S phase. J Radiat Res. 55(4):707-712 (2014)
  • Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes Cells. 19 (10): 743-754. (2014)
  • Nakano, T., Miyamoto-Matsubara, M., Shoulkamy, M. I., Salem, A. M., Pack, S. P., Ishimi, Y., and Ide, H. Translocation and stability of replicative DNA helicases upon encountering DNA-protein cross-links. J Biol Chem 288, 4649-4658. (2013)
  • Shoulkamy, M. I., Nakano, T., Ohshima, M., Hirayama, R., Uzawa, A., Furusawa, Y., and Ide, H. Detection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs. Nucleic Acids Res 40, e143. (2012)
  • Nakano, T., Ouchi, R., Kawazoe, J., Pack, S. P., Makino, K., and Ide, H. T7 RNA polymerases backed up by covalently trapped proteins catalyze highly error prone transcription. J Biol Chem 287, 6562-6572. (2012)
  • Tsuda M, Tanaka M, Mushiake M, Takahashi J, Tanaka K, Watase J, Fujisawa J, Miwa M. Novel pathway of centrosome amplification that does not require DNA lesions. Cancer Sci. 103(2), 191-196 (2012)
  • Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K. Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A. 108(16): 6492-6496(2011)
  • Ide, H., Shoulkamy, M. I., Nakano, T., Miyamoto-Matsubara, M., and Salem, A. M. Repair and biochemical effects of DNA-protein crosslinks. Mutat Res 711, 113-122. (2011)
  • Salem, A. M., Nakano, T., Takuwa, M., Matoba, N., Tsuboi, T., Terato, H., Yamamoto, K., Yamada, M., Nohmi, T., and Ide, H. Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli. J Bacteriol 191, 5657-5668. (2009)
  • Nakano, T., Katafuchi, A., Matsubara, M., Terato, H., Tsuboi, T., Masuda, T., Tatsumoto, T., Pack, S. P., Makino, K., Croteau, D. L., Van Houten, B., Iijima, K., Tauchi, H., and Ide, H. Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem 284, 27065-27076.(2009)
  • Nakano, T., Morishita, S., Katafuchi, A., Matsubara, M., Horikawa, Y., Terato, H., Salem, A. M., Izumi, S., Pack, S. P., Makino, K., and Ide, H. Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-protein crosslinks. Mol Cell. 28, 147-158. (2007)
  • Nakano, T., Katafuchi, A., Shimizu, R., Terato, H., Suzuki, T., Tauchi, H., Makino, K., Skorvaga, M., Van Houten, B., and Ide, H. Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress. Nucleic Acids Res 33, 2181-2191. (2005)
  • Nakano, T., Asagoshi, K., Terato, H., Suzuki, T., and Ide, H. Assessment of the genotoxic potential of nitric oxide-induced guanine lesions by in vitro reactions with Escherichia coli DNA polymerase I. Mutagenesis 20, 209-216. (2005)
  • Katafuchi, A., Nakano, T., Masaoka, A., Terato, H., Iwai, S., Hanaoka, F., and Ide, H. Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. J Biol Chem 279, 14464-14471. (2004)
  • Nakano, T., Terato, H., Asagoshi, K., Masaoka, A., Mukuta, M., Ohyama, Y., Suzuki, T., Makino, K., and Ide, H. DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage. J Biol Chem 278, 25264-25272. (2003)


理学部A棟6階 A603号室